Electrospinning Device: Fractal network structure of silk fibroin molecules and its influence on silk spinning

Background

The silk spinning process is a model of green manufacturing. It is carried out at room temperature and pressure, using water as a solvent, and does not require chemical solvents, heat sources or energy-consuming traction devices. Similarly, electrospinning technology is also a green technology. The nanofiber membrane obtained by it has the advantages of adjustable morphology, high specific surface area, and controllable pore structure, which can provide more active centers for the adsorption of pollutants in water and the atmosphere. This shows that both are environmentally friendly and meet the requirements of sustainable development.

Tissue Repair and Regeneration

Electrospinning technology is widely used in biomedical scaffolds for tissue engineering repair and regeneration. It can simulate the structure of extracellular matrix (ECM) and provide ideal scaffold materials for tissue engineering repair and regeneration. The natural structure and biocompatibility of silk also make it a potential material in tissue repair. Both have common application prospects in the field of tissue repair.

Immunomodulation

Electrospinning fibers stand out for their applicability in immune engineering strategies. They can achieve immune regulation through macrophage polarization and neutrophil aggregation. In the study of Jeong-Yong Lee's team, it was mentioned that SP restored the immune homeostasis of immune senescent cells by improving B cell dysfunction. This suggests that both electrospinning and silk spinning processes are associated with immunomodulation, although their mechanisms of action may be different.

Nanofiber properties

Electrospinning nanofibers have attracted much attention due to their high surface area to volume ratio, controllable pore structure, and excellent physicochemical properties. Silk fibers are also known for their unique mechanical properties and biocompatibility. Both have the potential to prepare high-performance nanofibers, which is of great significance in fields such as biomedicine and environmental remediation.

Promoting cellular responses

Electrospinning fibers are able to guide a large number of cellular responses, including phenotypic differentiation and tissue maturation. The fractal network structure of silk protein molecules has an important influence on their mechanical properties, and this structure may also play an important role in the behavior of silk in cellular responses and tissue repair.

Summary

In summary, there are connections between electrospinning and silk spinning processes in terms of environmental friendliness, tissue repair, immunomodulation, nanofiber properties, and promotion of cellular responses. These connections suggest that both technologies have broad application potential in materials science and biomedicine.

Electrospinning Nanofibers Article Source:

https://doi.org/10.1021/acsnano.3c00105