Electrospinning Device: Double-crosslinked silk fibroin hydrogel as a bioactive diabetic wound dressing

Background

Double cross-linked hydrogels can be prepared into dressings with excellent mechanical properties and biocompatibility through electrospinning technology. These dressings can not only provide good wound coverage, but also promote wound healing by continuously releasing growth factors and exosomes. Electrospinning technology can produce nanofibers with specific microstructures and surface properties, which help to improve the adhesion of dressings to wound beds, while reducing bacterial adhesion and reducing the risk of infection.

Drug controlled release system

Electrospinning technology can be used to prepare drug-loaded nanofibers, which can be used as drug controlled release systems to continuously release antibiotics or other therapeutic molecules to reduce infection and promote healing of diabetic wounds. The addition of double cross-linked hydrogels can further improve the release kinetics of drugs and achieve more effective wound management.

Promote angiogenesis and tissue repair

Double cross-linked hydrogels can promote diabetic wound healing faster than PRP and silk protein alone by upregulating growth factor expression, downregulating matrix metalloproteinase-9 expression, promoting angiogenesis and re-epithelialization. Electrospinning can be used to prepare nanofibers containing pro-angiogenic factors, which can be embedded in hydrogels to promote vascularization and tissue repair in diabetic wounds.

Anti-inflammatory and antibacterial activity

Double-crosslinked hydrogels exhibit good anti-inflammatory and antibacterial activity, which is essential for the treatment of diabetic wounds. Electrospinning can be used to prepare nanofibers containing antibacterial and anti-inflammatory molecules, which can act directly on the wound bed to reduce inflammatory responses and infection risks.

Multifunctional integration

Electrospinning can prepare multifunctional integrated nanofibers, which can combine the excellent mechanical properties and bioactivity of double-crosslinked hydrogels to provide an integrated diabetic wound treatment strategy. For example, multiple functions such as drug controlled release, antibacterial and pro-angiogenesis can be integrated in the same nanofiber to achieve more effective wound healing.

Promote wound contraction and closure

Double-crosslinked hydrogels have shown the ability to promote diabetic wound healing faster than PRP and SP in in vivo experiments. Electrospinning can be used to prepare nanofibers with specific structures that can promote wound contraction and closure and accelerate the healing process.

Summary

In summary, the combination of electrospinning technology and double-crosslinked hydrogels provides a new therapeutic strategy for diabetic wound management, which is expected to become a new generation of diabetic wound dressings by providing excellent mechanical properties, sustained drug release, anti-inflammatory and antibacterial activities, and the ability to promote angiogenesis and tissue repair.

Electrospinning Nanofibers Article Source:

https://doi.org/10.1016/j.bioactmat.2023.05.002