Electrospinning Device: Innovative application of silk fibroin: research on silk fibroin composite sutures with anti-infection function

Background

Nanofibers prepared by electrospinning technology can provide excellent biocompatibility and bioactivity due to their high specific surface area and porous structure. Silk fibroin composite suture (SMG-VC-IB) also shows good biocompatibility, which is similar to the characteristics of electrospun nanofibers, both of which are conducive to cell adhesion and growth and promote wound healing.

Optimization of mechanical properties

Electrospinning technology can control the mechanical properties of nanofibers, such as strength and toughness, by adjusting process parameters. Silk fibroin composite sutures also achieve excellent mechanical properties through twist and cross-linking treatment, and can withstand large tension, which is crucial for the strength and stability of surgical sutures.

Preparation of drug carriers

Electrospinning technology is often used to prepare drug-loaded nanofibers for controlled drug release. Silk fibroin composite sutures achieve sustained release of anti-infective drug vancomycin and analgesic ibuprofen through coating and drug loading, which is similar to the application of electrospinning technology in the preparation of drug carriers.

Antibacterial and anti-inflammatory properties

Electrospinning technology can be used to prepare nanofibers with antibacterial and anti-inflammatory properties, which can be achieved by loading antibacterial agents or anti-inflammatory drugs. Silk fibroin composite sutures showed anti-infection effects by adsorbing vancomycin and relieved pain and inflammation by releasing ibuprofen, which echoes the application of electrospinning technology in the field of antibacterial and anti-inflammatory.

Pain management

Electrospinning technology can be used to prepare nanofibers with pain management functions, such as by loading analgesics. Silk fibroin composite sutures provide an effective postoperative pain management method by embedding ibuprofen, which is consistent with the application of electrospinning technology in pain management.

Cost-effectiveness and scalability

Electrospinning technology is widely used in industrial production due to its scalability and cost-effectiveness. As a natural material, silk fibroin has the advantages of low cost and easy access. Electrospinning technology can further reduce production costs and improve the market competitiveness of silk fibroin-based products.

Summary

In summary, there is a close connection between electrospinning technology and silk fibroin composite sutures in terms of biocompatibility, mechanical properties, drug carrier preparation, antibacterial and anti-inflammatory properties, and pain management. These connections indicate that electrospinning technology has important application potential in developing new surgical sutures and improving surgical efficacy.

Electrospinning Nanofibers Article Source:

https://doi.org/10.1016/j.compositesb.2023.110729