Electrospinning Device: Intra-articular injection of silk hydrogel microspheres with enhanced mechanical and structural stability can alleviate osteoarthritis

Application of Silk Fibroin/BDDE Hydrogel Balls in the Treatment of Osteoarthritis

Pain relief as a biolubricant: Silk Fibroin/BDDE hydrogel balls have high elasticity and stability, and can play a long-term lubricating function in the joint cavity, reduce joint friction, and thus significantly reduce the pain caused by osteoarthritis. Its residence time in the joint cavity is more than 1 month, which can provide continuous pain relief.

Promote cartilage repair: Hydrogel balls can effectively reduce cartilage damage, prevent the loss of extracellular matrix (ECM) in cartilage tissue and the death of chondrocytes. Its biological lubrication and buffering effects help protect cartilage and promote the repair and regeneration of cartilage tissue.

Good biocompatibility: In animal experiments, silk fibroin/BDDE hydrogel balls showed good biocompatibility and did not cause obvious inflammatory reactions or immune responses. Its smooth, hydrophilic surface and tissue-compatible properties enable it to be safely used in the body.

Application of electrospinning equipment in the preparation of silk fibroin hydrogel

Preparation of nanofiber structure: Electrospinning equipment can prepare silk fibroin nanofibers with specific structures and properties. These nanofibers can be used to construct finer hydrogel structures and further optimize their performance. For example, silk fibroin nanofibers prepared by electrospinning technology can be compounded with BDDE to form composite materials with better mechanical properties and biocompatibility.

Regulating the microstructure of hydrogels: Electrospinning technology can accurately control the diameter and morphology of nanofibers by adjusting parameters such as the concentration, viscosity, and electric field strength of the spinning solution. This allows the pore structure and pore size of silk fibroin hydrogels to be precisely regulated, thereby better meeting the needs of osteoarthritis treatment.

Loading bioactive substances: Electrospinning equipment can prepare nanofiber hydrogels loaded with bioactive molecules. For example, growth factors and drugs that promote cartilage repair are loaded into silk fibroin nanofibers, and then combined with BDDE. By controlling the release rate, the continuous effect of bioactive substances in the joint area is achieved.

Summary

In summary, silk fibroin/BDDE hydrogel balls show good application effects in the treatment of osteoarthritis, and electrospinning equipment provides strong technical support for its preparation. Through electrospinning technology, silk fibroin nanofiber hydrogel with specific structure and properties can be prepared, and the performance of silk fibroin/BDDE hydrogel balls can be further optimized to improve their application effect in the treatment of osteoarthritis.

Electrospinning Nanofibers Article Source:

https://doi.org/10.1016/j.biomaterials.2022.121611