Electrospinning Equipment: An injectable light-curable silk fibroin hydrogel for constructing an antioxidant microenvironment for skin repair

Application of SF-g-SDA hydrogel in skin repair

Constructing an antioxidant microenvironment: SF-g-SDA hydrogel effectively protects cells from damage caused by oxidative stress and supports normal cell life activities through its phenolic hydroxyl-mediated antioxidant properties. This provides a favorable microenvironment for skin repair, helps reduce inflammatory responses, and promotes normal cell growth and functional recovery.

Promoting cell adhesion and vascularization: In in vitro experiments, SF-g-SDA hydrogel showed good cell compatibility and was able to promote cell adhesion and vascularization. Cell adhesion and vascularization are key steps in the skin repair process, which contribute to the formation of new tissues and the restoration of function.

Accelerating wound healing: In animal experiments, SF-g-SDA hydrogel showed better skin repair effects than commercial Tegaderm™. It can significantly accelerate wound healing, improve the deposition and arrangement of collagen in new tissues, and promote new blood vessel formation and hair follicle formation, thereby improving the quality and speed of skin repair.

Application of electrospinning equipment in the preparation of SF-g-SDA hydrogel

Preparation of nanofiber structure: Electrospinning equipment can prepare silk fibroin nanofibers with specific structures and properties. These nanofibers can be used to construct finer hydrogel structures and further optimize their performance. For example, silk fibroin nanofibers prepared by electrospinning technology can be compounded with methacrylated dopamine to form a composite material with better mechanical properties and antioxidant properties, providing more stable support and better protection for skin repair.

Regulating the microstructure of hydrogel: Electrospinning technology can accurately control the diameter and morphology of nanofibers by adjusting parameters such as the concentration, viscosity, and electric field strength of the spinning solution. This allows the pore structure and pore size of SF-g-SDA hydrogel to be precisely regulated, thereby better meeting the needs of skin repair and providing a suitable microenvironment for cell adhesion, growth, and the formation of new tissues.

Loading bioactive substances: Electrospinning equipment can prepare nanofiber hydrogels loaded with bioactive molecules. For example, growth factors and drugs that promote skin repair are loaded into silk fibroin nanofibers, and then combined with methacrylated dopamine. By controlling the release rate, the sustained action of bioactive substances in the skin repair site can be achieved. This can not only enhance the biological function of the hydrogel, but also further improve its effect in skin repair.

Summary

In summary, SF-g-SDA hydrogel shows good application effect in skin repair, and electrospinning equipment provides strong technical support for its preparation. Through electrospinning technology, silk fibroin nanofiber hydrogel with specific structure and performance can be prepared, and the performance of SF-g-SDA hydrogel can be further optimized to improve its application effect in skin repair.

Electrospinning Nanofibers Article Source:

https://doi.org/10.1039/D3TB02214E