Copyright © 2022 Foshan MBRT Nanofiberlabs Technology Co., Ltd All rights reserved.Site Map
Osteoarthritis (OA) is a degenerative disease that affects articular cartilage and is characterized by joint pain, swelling, and limited mobility. With the aging population and increasing obesity rates, the prevalence of OA is increasing, placing a heavy medical burden on patients and society.
Traditional OA treatments focus on relieving symptoms rather than changing the course of the disease. In recent years, with the development of nanotechnology and regenerative medicine, micro/nanosphere systems and electrospinning technology have shown great potential and application prospects in OA treatment.
Silk fibroin has attracted extensive attention in the field of bone tissue engineering due to its excellent biocompatibility, biodegradability, and mechanical properties. By assembling biocompatible polydopamine nanoparticles (PDA NPs) at the mesoscopic scale, SF scaffolds with near-infrared (NIR) light response can be constructed. These scaffolds not only have improved structure and performance for bone therapy and bone reconstruction, but also have good photothermal effects.
Electrospinning technology has been widely studied to enhance the regenerative capacity of bones. SF scaffolds prepared by electrospinning can mimic the structure and biological function of the extracellular matrix, thereby enhancing bone regeneration. In addition, electrospinning technology can also be used to prepare SF scaffolds with specific nanopatterns to regulate stem cell function.
The functionalized SF scaffolds showed significant killing effects on MG63 tumor cells under NIR laser irradiation, indicating that they have good application value in the field of photothermal therapy. The photothermal effect can enhance the multifunctional fiber scaffold to promote bone regeneration. For example, black phosphorus nanosheets (BP NSs) are doped in electrospun polycaprolactone nanofibers to give them good NIR responsiveness, thereby promoting bone repair.
The SF scaffold constructed by Associate Professor Lin Naibo of Xiamen University, through PDA NPs functionalization, shows the potential for photothermal therapy and tissue repair of bone tumors under NIR light triggering. This scaffold uses optical fiber to improve the penetration of NIR light into tissues, further enhancing its application potential in photothermal therapy.
The functionalized SF scaffolds showed excellent biocompatibility and effective photothermal cytotoxicity to human osteosarcoma cells (MG63) under NIR laser, which further confirmed its potential application in tumor therapy.
In summary, the combination of functionalization of SF scaffolds, electrospinning technology and photothermal therapy provides a new strategy for bone tumor treatment and bone regeneration. The functionalized SF scaffolds prepared by electrospinning technology can not only improve the effect of bone treatment and reconstruction, but also effectively kill tumor cells through photothermal effect, showing broad application prospects in bone tissue engineering.
Electrospinning Nanofibers Article Source:
https://doi.org/10.1002/adfm.202007188
