Electrospinning Device: New research on osteoarthritis treatment-injectable regenerative silk protein micro/nanospheres

Drug delivery system

Electrospinning technology is used to prepare drug-loaded nanofibers, which can be used as drug delivery systems to improve drug delivery capacity and reduce drug burst release. For example, loading nanocarriers into electrospun fibers through electrospinning technology can improve drug delivery capacity.

Drug release capacity of nanofiber membranes

The researchers used nanofiber membranes prepared by electrospinning technology to study the drug release capacity of electrospun nanofiber membranes prepared with different proportions of vesicles, and found that the amount of drug released can be controlled by adjusting the ratio of vesicles and micelles.

In situ hydrogen production injection short fiber

A study developed a short fiber injectable material that can continuously generate hydrogen in situ to eliminate reactive oxygen species (ROS), relieve oxidative stress and inflammation, and promote tissue repair. This material combines H-Si nanosheets with high hydrogen production efficiency with GelMA short fibers through electrospinning technology, achieving in situ delivery of H-Si nanosheets and regulated hydrogen production rate.

Nanofibrous microspheres modified with metal phenol networks

Another study prepared gelatin/poly(L-lactide)-based nanofibrous microspheres by electrospinning combined with electrospraying and functionalized them with metal phenol networks to evaluate their potential for treating osteoarthritis in vitro and in vivo.

ROS-responsive nanofibrous membranes

Electrospinning technology has also been used to prepare ROS-responsive nanofibrous membranes for long-term drug release systems for sustained release of osteoarthritis. This nanofibrous membrane is responsive to hydrogen peroxide and exhibits excellent anti-inflammatory and antioxidant effects on IL-1β-induced chondrocytes.

Injectable "nano-micro" combined gene-hydrogel microspheres

Electrospinning technology has also been used to construct "nano-micro" combined gene-hydrogel microspheres for local treatment of osteoarthritis. This microsphere is formed by forming a complex with a therapeutic microRNA and a multifunctional gene carrier, which is then encapsulated in a hydrogel microsphere to mitigate the degradation of articular cartilage.

Summary

In summary, electrospinning technology plays an important role in the research of micro/nanosphere systems in the treatment of osteoarthritis. It can not only prepare nanofibers with specific drug release properties, but also combine other materials and technologies, such as metal phenol networks, ROS-responsive materials, gene therapy, etc., to improve the treatment effect and the quality of life of patients.

Electrospinning Nanofibers Article Source:

https://doi.org/10.1002/smll.202405049