Electrospinning Device: Photopolymerized silk fibroin gel for advanced burn wound care

Background

This study used white light responsive photopolymerization technology and photooxidation of tyrosine for gelation to prepare a new type of silk fibroin (SF) hydrogel dressing (SFD) for the treatment of burn wounds. This dressing has good swelling ability, water retention ability, and in vitro cell compatibility.

Application of electrospinning technology in silk fibroin materials

Electrospinning technology is an efficient method for preparing nanofibers, which can be used to manufacture silk fibroin-based nanofiber scaffolds. These scaffolds show great potential in the fields of tissue engineering and wound healing due to their unique properties.

Physical properties and rheological behavior of silk fibroin hydrogel

The study characterized the physical properties and rheological behavior of SF hydrogel and found that SF gel has good swelling and moisture retention, which is very important for keeping the wound moist and promoting healing.

Drug release characteristics of silk fibroin hydrogel

In this study, THC was used as a model drug to study the in vitro drug release profile of SFD, showing an initial burst release and subsequent gradual release, which is an important characteristic for local drug delivery.

In vivo performance of silk fibroin hydrogel

The healing effect of SFD was tested on a rat second-degree burn model. The results showed that the SFD treatment group had no scar healing, indicating that SFD dressing materials have good application prospects in the treatment of burn wounds.

Advantages of electrospinning technology

Electrospinning technology can prepare silk fibroin nanofibers with high specific surface area and high porosity. These properties are conducive to cell attachment and growth, as well as the transportation of nutrients and metabolic waste, which are particularly important for tissue engineering and wound healing.

Combination of silk fibroin hydrogel with electrospinning technology

Combining silk fibroin hydrogel with electrospinning technology can prepare dressings with good biocompatibility and bioactivity. This dressing can not only provide wound protection, but also promote wound healing and regeneration.

Summary

In summary, silk fibroin hydrogel, as a new type of bioactive dressing, has shown excellent performance in the treatment of burn wounds. The application of electrospinning technology provides new possibilities for the development of silk fibroin materials, especially in the preparation of nanofiber scaffolds with specific structures and functions. These research results provide new perspectives for the application of silk fibroin in the biomedical field and lay the foundation for future clinical applications.

Electrospinning Nanofibers Article Source:

https://doi.org/10.1016/j.ijbiomac.2023.123569