Electrospinning Device: Silk fibroin-based injectable sealant for rapid hemostasis and wound repair

Background

Uncontrolled blood loss poses a fatal risk, while the latest developed sealants still have common limitations such as controversial composition, degradability, mechanical strength or gel time. In this paper, a series of injectable sealants based on silk fibroin (SF) were developed. In the absence of any exogenous factors, the increased expression of VEGF and PDGF led to positive feedback regulation of fibroblast and vascular endothelial cell growth/proliferation and promoted wound healing. These findings indicate that small amounts of assembled peptides can accelerate the gel transition of silk fibroin under limited physiological conditions, while amino acid-based injectable sealants have obvious advantages in biocompatibility, degradability, rapid gelation and matching strength, and have strong potential as next-generation biomedical materials.

Supramolecular interactions and in vivo degradation

Supramolecular interactions and in vivo degradation contribute to the infiltration of inflammatory host cells and the diffusion of cytokines, which is similar to the control of fiber morphology and properties by adjusting the electric field and solution parameters in electrospinning technology. Electrospinning technology enables the preparation of nanofibers with specific structures that can promote the diffusion of cytokines and the infiltration of cells.

Biocompatibility and degradability

Silk fibroin-based sealants exhibit good biocompatibility and degradability, which is consistent with the goal of using biocompatible materials (such as silk fibroin) in electrospinning technology. Electrospinning technology can produce degradable nanofibers, which are particularly important in biomedical applications.

Promote wound healing

Silk fibroin-based sealants can promote wound healing, which may be related to their ability to promote the expression of VEGF and PDGF, two growth factors that are essential for the growth/proliferation of fibroblasts and endothelial cells. Electrospinning technology can produce nanofibers containing these growth factors to promote wound healing.

Application of electrospinning technology

Electrospinning technology has a wide range of applications in the textile industry, including the preparation of nanofibers with specific functions. These fibers can be used to prepare hemostatic materials, such as silk fibroin-based sealants, which can quickly gel and provide mechanical strength to control bleeding.

Development of biomedical materials

As a new natural medical material with great potential, silk fibroin has broad application prospects in the field of biomedical materials. Electrospinning technology can use natural polymer materials such as silk fibroin to develop new biomedical materials, such as hemostasis and wound repair materials.

Summary

In summary, injectable sealants based on silk fibroin are closely related to electrospinning technology in terms of rapid hemostasis, wound repair, biocompatibility, degradability, and promotion of wound healing. Electrospinning technology can provide technical support for the development of these biomedical materials by precisely controlling the morphology and properties of the fibers to meet specific clinical needs.

Electrospinning Nanofibers Article Source:

https://doi.org/10.1002/adhm.202301310