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Rapid hemostasis: The platform utilizes the hemostatic properties of natural silk fibroin (SF) and is composed of shape memory SF sponge, which can promote blood coagulation. Compared with untreated blood, the in vitro hemostasis time is shortened by about 82%, significantly improving the hemostasis efficiency.
Bleeding detection and diagnosis: The platform is used as a capacitive sensor, which can detect bleeding and distinguish blood from other body fluids (such as serum and water) through capacitance changes. This detection method can achieve early detection and continuous monitoring of bleeding.
Anti-infection performance: Silver nanowire (AgNW) electrodes have a broad spectrum of anti-infection efficacy, with an antibacterial effect of 95% against Escherichia coli and an antibacterial activity of 70% against Staphylococcus aureus, which can effectively prevent wound infection.
Good biocompatibility: The platform exhibits excellent biocompatibility and gradually biodegrades in the body without causing severe local or systemic inflammatory reactions.
Preparation of nanofiber structure: Electrospinning equipment can prepare silk protein nanofibers with specific structure and properties. These nanofibers can be used to construct the SF sponge layer in the platform, making it have better mechanical properties and blood absorption capacity.
Regulating the microstructure of the platform: By adjusting the parameters such as spinning solution concentration, viscosity, and electric field strength during the electrospinning process, the diameter and morphology of the nanofibers can be precisely controlled. This allows the pore structure and pore size of the AgNW-SF therapeutic diagnostic platform to be precisely regulated, thereby better meeting the needs of bleeding management.
Loading bioactive substances: Electrospinning equipment can prepare nanofibers loaded with bioactive molecules. For example, bioactive substances that promote blood coagulation or anti-inflammatory effects are loaded into silk protein nanofibers, and the release rate is controlled to achieve the continuous effect of bioactive substances at the wound site.
In summary, the AgNW-SF therapeutic diagnostic platform shows good application effects in bleeding management, and electrospinning equipment provides strong technical support for its preparation. Through electrospinning technology, silk fibroin nanofibers with specific structures and properties can be prepared, further optimizing the performance of the AgNW-SF therapeutic diagnostic platform and improving its application effect in bleeding management.
Electrospinning Nanofibers Article Source:
https://doi.org/10.1002/advs.202301406
