Electrospinning Equipment: Osteogenic potential and performance of silk fibroin-based injectable biocement system

Application of CFIB biocement in bone defect repair

Enhanced osteogenic potential: Silk fibroin (SF) can significantly increase osteoconductivity and new bone formation when combined with bioactive ingredients such as tetracalcium phosphate and monetite. In CFIB composite materials, the calcium phosphate component is almost completely converted into nanohydroxyapatite, which helps promote the attachment and growth of osteoblasts, thereby accelerating the repair of bone defects.

Improved mechanical properties: The compressive strength of CFIB composite bone cement is reduced to 14MPa, which is close to the strength of cancellous bone. This moderate mechanical property enables CFIB biocement to withstand a certain physiological load without causing excessive pressure on the growth of new bone tissue, which is conducive to the healing and remodeling of bone defects.

Regulated setting time: In CFIB10, when the addition amount of SF is 10wt%, the setting time of the material increases with the increase of SF content, up to 25 minutes. This adjustable setting time allows CFIB biocement to adjust its curing speed according to surgical needs and the specific conditions of the bone defect site, making it easier for doctors to operate and fill bone defects.

Application of electrospinning equipment in the preparation of CFIB biocement

Preparation of nanofiber structure: Electrospinning equipment can prepare silk fibroin nanofibers with specific structure and properties. These nanofibers can be compounded with calcium phosphate particles to form composite materials with excellent mechanical properties and biocompatibility. For example, silk fibroin nanofibers prepared by electrospinning technology can be evenly dispersed in the calcium phosphate matrix to enhance the overall performance of the material.

Regulating the microstructure of cement: Electrospinning technology can accurately control the diameter and morphology of nanofibers by adjusting parameters such as the concentration, viscosity, and electric field strength of the spinning solution. This allows the pore structure and pore size of CFIB biocement to be precisely regulated, thereby better meeting the needs of bone defect repair. For example, a nanofiber network with appropriate porosity and uniform pore size can be prepared to provide a good microenvironment for the adhesion, growth, and formation of new bone tissue of osteoblasts.

Loading bioactive substances: Electrospinning equipment can prepare nanofiber cement loaded with bioactive molecules. For example, growth factors and drugs that promote bone repair are loaded into silk fibroin nanofibers and then combined with calcium phosphate particles. By controlling the release rate, the sustained action of bioactive substances in the bone defect site can be achieved. This can not only enhance the biological function of CFIB biocement, but also further improve its effect in bone defect repair.

Summary

In summary, silk fibroin/tetracalcium phosphate/moclinic calcium phosphate biocement shows good application effect in bone defect repair, and electrospinning equipment provides strong technical support for its preparation. Through electrospinning technology, nanofiber composites with specific structures and properties can be prepared, further optimizing the performance of CFIB biocement and improving its application effect in bone defect repair.

Electrospinning Nanofibers Article Source:

https://doi.org/10.1002/jbm.b.34945