Electrospinning Academic News

The effect of hypoxia-mimicking responses on improving the regeneration of artificial vascular grafts 2021-03-11

Cellular transition to hypoxia following tissue injury, has been shown to improve angiogenesis and regeneration in multiple tissues. To take advantage of this, many hypoxia-mimicking scaffolds have been prepared, yet the oxygen access state of implanted artificial small-diameter vascular grafts (SDVGs) has not been investigated. Therefore, the oxygen access state of electrospun PCL grafts implanted into rat abdominal arteries was assessed. The regions proximal to the lumen and abluminal surfaces of the graft walls were normoxic and only the interior of the graft walls was hypoxic.In vitro experiments indicated that DMOG-loaded PCL mats had significant biological advantages, including: promotion of human umbilical vein endothelial cells (HUVECs) proliferation, migration and production of pro-angiogenic factors; and the stimulation of M2 macrophage polarization, which in-turn promoted macrophage regulation of HUVECs migration and smooth muscle cells (SMCs) contractile phenotype. These be

Conditioned medium-electrospun fiber biomaterials for skin regeneration 2021-03-11

Conditioned medium (CM) contains variety of factors secreted by cells, which directly regulate cellular processes, showing tremendous potential in regenerative medicine. Here, for the first time, we proposed a novel regenerative therapy mediated by biodegradable micro-nano electrospun fibers loaded with highly active conditioned medium of adipose-derived stem cells (ADSC-CM). ADSC-CM was successfully loaded into the nanofibers with biological protection and controllable sustained-release properties by emulsion electrospinning and protein freeze-drying technologies. In vitro, ADSC-CM released by the fibers accelerated the migration rate of fibroblasts; inhibited the over proliferation of fibroblasts by inducing apoptosis and damaging cell membrane; in addition, ADSC-CM inhibited the transformation of fibroblasts into myofibroblasts and suppressed excessive production of extracellular matrix (ECM). In vivo, the application of CM-biomaterials significantly accelerated wound closure and im

Electrospun fixed dose combination fibers for the treatment of cardiovascular disease 2021-03-10

Fixed dose combinations (FDCs) offer an accessible way to simplify complex therapeutic regimens by the simultaneous presentation of multiple drugs in a single entity to the patient. However, encapsulation of hydrophobic drugs into FDCs possess a number of technical challenges. Electrospun nanofibers offer a convenient way to incorporate multiple hydrophobic drugs into a single formulation in a single step, via the use of an appropriate organic solvent system during fabrication. In this study, we report a series of novel fiber formulations comprising ethyl cellulose loaded with two hydrophobic drugs, spironolactone and nifedipine, either individually or in combination. The drugs are found to be present in the fibers in the form of amorphous solid dispersions, and these are stable at room temperature for 4 months. The products showed extended release profiles over more than 30 h. This formulation strategy offers potential to manage chronic cardiovascular conditions and overcome patient r

Ethylcellulose-based drug nano depots fabricated using a modified triaxial electrospinning 2021-03-10

New strategies based on advanced technologies are highly desired for expanding the applications of biological macromolecules in the applied scientific fields. In the present study, a new kind of core-shell nano depots were designed, in which the shell section was a drug-polymer composite and the core section was a drug reservoir. With ethyl cellulose and ketoprofen as a filament-forming polymeric matrix and a model drug, respectively, a triaxial electrospinning apparatus was developed to conduct both coaxial and triaxial processes, by which monolithic nanofibers F1 and core-shell nano depots F2 were successfully prepared. Although both of them had the same double components, their different nanostructures generated considerable differences in providing drug sustained release profiles. The core-shell nanofiber depots F2 were able to provide a better zero-order drug release profile: no initial burst release, smooth sustained release effect, and smaller tailing-off release for a nice zero

Electrospun fibrous membrane with controlled hierarchical structure and wettability for effective emulsion separation 2021-03-08

Porous membranes are widely used for filtration, especially those with homogenous pore size and strong mechanical strength. Here, we develop a programmable electrospinning system and fabricate porous membranes consisted of orthogonally aligned nanofibers. The porous fibrous membranes possess more homogeneous pore size and stronger mechanical strength when compared to traditional porous membrane with disordered nanofibers. By physically modifying the membrane surface with PTFE nanoparticles, we obtain a filter membrane, which has both large oil contact angle in water and large water contact angle in oil. Synergism between hierarchical structure and surface property realizes a high separation efficiency of both oil-in-water and water-in-oil emulsions. The technique to control the structure of fibrous membrane, combined with the method to modify the surface of nanofibers, provides a great opportunity to design advanced fibrous membrane for various applications.

Academic achievements of Prof. Yan Wei's team from Tsinghua University 2021-03-06

As the core of polymer chemistry, manufacture of functional polymers is one of research hotspots over the past several decades. Various polymers are developed for diverse applications due to their tunable structures and unique properties. However, traditional step-by-step preparation strategies inevitably involve some problems, such as separation, purification, and time-consuming. The multicomponent reactions (MCRs) are emerging as environmentally benign synthetic strategies to construct multifunctional polymers or composites with pendant groups and designed structures because of their features, such as efficient, fast, green, and atom economy. This mini review summarizes the latest advances about fabrication of multifunctional fluorescent polymers or adsorptive polymeric composites through different MCRs, including Kabachnik–Fields reaction, Biginelli reaction, mercaptoacetic acid locking imine reaction, Debus–Radziszewski reaction, and Mannich reaction. The potential applications of

Electrospinning and melting electrostatic printing composite manufacturing small diameter artificial blood vessel stent 2021-02-06

Small-diameter vascular stents (less than 6 mm) have a huge demand in clinic, but their clinical application is limited due to the occlusion of the graft, intimal hyperplasia, and thrombosis due to the small diameter. Electrospinning and melting electrostatic printing composite manufacturing provides a new method for the manufacture of small-diameter vascular stents.

How To Use Near Field Direct Writing Electrospinning Technology For Inducing The Regeneration of Corneal Stroma 2021-02-06

Recently, by the Foshan Lepton Precision M&C Tech Co., Ltd customer, International Graduate School of Tsinghua University in Shenzhen, Shengli Mi and Wei Sun Group, have made great progress in the field of corneal stromal regeneration, relevant results were published in Nature Communications Journal on March 18, 2020, titled " Fiber reinforced GelMA hydrogel to induce the regeneration of corneal stroma”.

Complete Production Solution for Biodegradable Nanofiber Mask Materials 2021-02-06

We provide a complete set of biodegradable nanofiber mask material production solution, including biodegradable PLA spunbond layer, degradable PLA nanofiber filter media layer, degradable PLA ear strap, nose bridge and other material solutions. Foshan Lepton Precision M&C Technology Co., Ltd. provides degradable PLA nanofiber filter layer production technology and a complete set of degradable materials supply.

Review of electrospinning oriented nanofiber scaffolds on wound dressings 2021-02-06

Electrospinning has unique advantages in producing oriented nanofibers, which help to assist wound healing and promote cell proliferation.

Upcoming books on electrospinning applications in the second half of 2022 2021-02-06

This paper introduces three books on Electrospinning in the second half of 2022

Academic News