Electrospinning Machine Resources

ActiVLayr nanofiber technology 2021-03-19

Revolution Fibres Ltd., a global leader in nanofiber production has developed cutting-edge industrial-scale electrospinning infrastructure using its proprietary “sonic” electrospinning technology. In collaboration with global leaders in food and marine science, Revolution Fibres has developed a unique extraction process to obtain denatured whole chains of hoki fish collagen, suitable for electrospinning. ActiVLayr patented technology is made from electrospun collagen type I nanofiber membranes carrying a wide range of natural extracts and active cosmetic ingredients. ActiVLayr technology is one of the fastest delivery mechanisms in the skincare industry, fully dissolving into the skin in less than 10 seconds. ActiVLayr under-eye patches and facemasks are currently being commercialized in Latin America and Asia under the marketing of other established and upcoming brands in the cosmetic and skincare markets. ActiVLayr applications, clinical results, market trends, and future development

A New Carrier for Advanced Cosmeceuticals 2021-03-19

Cosmetic products are generally formulated as emulsions, ointments, solutions or powders containing active ingredients. However, science advancement in both active carriers and ingredients has streamlined the process through which many cosmetic products by their delivery systems can induce modifications on the skin physiology. The so-called cosmeceuticals, in fact, may induce modifications on the skin physiology, modifying, for example, transepidermal water loss, keratinocytes cohesion and turnover, modulating the inflammatory cascade, and/or altering the surface microbiota by the activity of the preservatives content. In this study, we would like to introduce an innovative category of cosmeceuticals made by biodegradable nonwoven tissues. These cosmeceutical tissues, produced through the use of natural fibers, may bind different active ingredients and therefore become effective as antibacterial, anti-inflammatory, sun-protective, whitening, or anti-aging products, depending on the ing

Nanofibers in Cosmetics 2021-03-19

Nanofibers form the broadest class of nanomaterials due to their unique properties.High surface-area-to-volume ratios, low diameters, high strength values, low basis weights, high porosities, and small pore sizes make them good candidates for numerous applications. Cosmetics are one of these important application areas. Excellent interaction with environment (e.g., skin or damaged tissue), increased loading capacity for agents, high liquid absorption capacities, high oxygen, and water vapor permeability values are provided by characteristic properties of nanofibers. They are used as therapeutics, facial masks, skin care, and renewal products. This chapter will provide an overview of nanofibers in cosmetics. A brief history of cosmetics, different types of nanomaterials used in cosmetics, nanofiber properties, and production methods are described in this chapter. Novel applications of nanofibers in cosmetics are also mentioned.

Nanofibrous cosmetic face mask for transdermal delivery of nano gold: synthesis, characterization, release and zebra fish employed toxicity studies 2021-03-19

This study involves the generation of gold nanoparticles (Au NPs) via a novel natural/non-toxic methodology using tea and orange-peel extracts. These were then embedded into a novel blend composed of a polyethylene oxide and gelatin (PEO-Gel) fibre mat. The scanning electron microscopy results indicated that the addition of both collagen (COL) and ascorbic acid (AA) into the PEO-Gel system (PEO-Gel-AA-COL system) enhances the Au NP incorporation into nanofibres leading to a diameter of 164.60 ± 20.95 and 192.43 ± 39.14 nm in contrast to the spraying observed with the Au PEO-Gel system alone. Releasing studies conducted over 30 min indicated that the PEO-Gel-AA-COL-orange peel Au (OpAu) system accounts for a higher content of Au release than the green tea Au (GtAu) NP system where a maximum release could be attained within 10–30 min depending on the amount of Au NPs that have been incorporated. Moreover, the transdermal diffusion studies conducted using Strat membrane indicated that Au

Engineering optimization of commercial facemask formulations capable of improving skin moisturization 2021-03-19

The stratum corneum is the biggest obstacle in cosmetics with respect to skin moisturization. Many approaches have been taken to overcome the barrier, one of which is incorporating natural cosmeceuticals into cosmetic products to enhance moisturization effects. Here, a commercial facemask formulation was electrospun to develop dry facemasks capable of hosting cosmeceuticals within the pores of incorporated mesoporous silica.

Novel Vitamin and Gold-Loaded Nanofiber Facial Mask for Topical Delivery 2021-03-19

L-ascorbic acid has been widely used in cosmetic and dermatological products because of its ability to scavenge free radicals and destroy oxidizing agents. However, it is chemically unstable and can easily be oxidized. The current cosmetic facial masks available in the market are pre-moistened, which means that the aqueous fluid content of the mask may oxidize some of the unstable active ingredients such as ascorbic acid. This work presents an anti-wrinkle nanofiber face mask containing ascorbic acid, retinoic acid, gold nanoparticles, and collagen. This novel face mask will only be wetted when applied to the skin, thus enhancing product stability. Once moistened, the content of the mask will gradually dissolve and release the active ingredients and ensure maximum skin penetration. The high surface area-to-volume ratio of the nanofiber mask will ensure maximum contact with the skin surface and help to enhance the skin permeation to restore its healthy appearance. Electrospun fiber mats

Development of Natural Facial Mask for Skincare from Local Materials 2021-03-19

This research aims to develop a natural facial mask from local materials. The latter are natural materials which could be found locally. In this study, we have selected local materials such as silk fibroin, mulberry, and chitosan. Silk fibroin is active ingredient in the prototype because of its high antioxidant activity. On the other hand, the mulberry extract is antioxidant and antibacterial activity in the facial mask. In the meantime, chitosan could be extracted from local materials such as squid pen and shrimp shells. Chitosan was chosen to be material of the facial mask to nourish good mechanical properties of the mask's structure. The research has developed the natural facial mask with the product design technique. Also, this study integrates consumer's requirements and quality function deployment (QFD) to transform consumer's needs into technical design specifications. The result show that the consumer's requirements which obtain high score are certification standard, ability t

Preliminary Studies on an Innovative Bioactive Skin Soluble Beauty Mask Made by Combining Electrospinning and Dry Powder Impregnation 2021-03-19

The world of cosmetics is now aiming at biobased materials which are skin-compatible and can be used to generate more sustainable beauty masks with enhanced bioactivity. This work presents, in this line of interest, the combination of two innovative technologies, namely electrospinning and dry powder impregnation, to generate biobased skin soluble electrospun pullulan carriers dry impregnated with chitin nanofibrils-nanolignin-glycyrrethinic acid (CLA) complexes, as effective biobased and skin compatible beauty masks. The scalability of the pullulan electrospun carrier and bioactive complexes impregnation were optimized and the morphology evaluated. Subsequently, skin compatibility and mask effectiveness were investigated in vitro and in vivo. The results showed that cell viability was optimal for both impregnated and neat pullulan fibers. Additionally, the CLA impregnated pullulan fibers were able to upregulate the endogenous antimicrobial molecule HBD-2. Preliminary studies in vivo i

Electrospinning process: Versatile preparation method for biodegradable and natural polymers and biocomposite systems applied in tissue engineering and drug delivery 2021-03-19

Over the past two decades, the electrospinning process has shown a great potential in various applications, such as membrane filtration, catalytic processes, fibrous-sensor applications, drug delivery and tissue engineering, due to ability of facile producing high surface-to-volume fibrous structure. The most appealing electrospinning characteristic has shown to be the mimicking nano-scale fibrous topography of extracellular matrix (ECM) in tissue engineering field. The wide range of electrospinnable synthetic biodegradable and natural polymers offers fabrication of fibrous nano-structures with specific biological responses and mechanical properties. Conducting different processing parameters (needle geometry, tip-to-collector distance, electric field strength, collector composition and geometry) allows the altering of fiber size, density, alignment and overall morphology. So far, electrospinning process has shown limitless application in tissue engineering and drug delivery. The follo

Tough, anti-freezing and non-drying double network organohydrogels 2021-03-19

Herein, a novel double network polyvinyl alcohol/gelatin/glycerol (PVA/GEL/GL) organohydrogel is reported and fabricated. The existence of GEL improves the high mechanical strength based on the strong hydrogen bonds from PVA and GL, endowing the organohydrogels with excellent flexibility and biocompatibility. Especially, PVA/GEL/GL organohydrogels can maintain excellent mechanical flexibility at −25 °C, and possess remarkable non-drying even at 85 °C. It also exhibits good mildewproof property after 15 days. Meanwhile, remoldability endows organohydrogels to be recycled and reused, even as substitute materials for soil to cultivate plants. Thus, PVA/GEL/GL organohydrogels as a biological material have great potential great potential in fields of biomedicine, and even industry and agriculture.

Surface-functionalized electrospun nanofibers for tissue engineering and drug delivery 2021-03-19

Electrospun nanofibers with a high surface area to volume ratio have received much attention because of their potential applications for biomedical devices, tissue engineering scaffolds, and drug delivery carriers. In order to develop electrospun nanofibers as useful nanobiomaterials, surfaces of electrospun nanofibers have been chemically functionalized for achieving sustained delivery through physical adsorption of diverse bioactive molecules. Surface modification of nanofibers includes plasma treatment, wet chemical method, surface graft polymerization, and co-electrospinning of surface active agents and polymers. A variety of bioactive molecules including anti-cancer drugs, enzymes, cytokines, and polysaccharides were entrapped within the interior or physically immobilized on the surface for controlled drug delivery. Surfaces of electrospun nanofibers were also chemically modified with immobilizing cell specific bioactive ligands to enhance cell adhesion, proliferation, and differe

Processing nanoengineered scaffolds through electrospinning and mineralization suitable for biomimetic bone tissue engineering 2021-03-19

Processing scaffolds that mimic the extracellular matrix (ECM) of natural bone in structure and chemical composition is a potential promising option for engineering physiologically functional bone tissue. In this article, we report a novel method, by combining electrospinning and mineralization, to process a series of nano-fibrous scaffolding systems with desirable characteristics suitable for biomimetic bone tissue engineering. We have chosen two types of polymers, namely collagen and poly (lactic-co-glycolic acid) (PLGA), natural and synthetic of its kind, respectively, to electrospin into nano-fibrous scaffolds. The electrospun scaffolds have high surface area, high porosity and well connected open pore network. In order to mimic the chemical composition of native bone ECM, the electrospun scaffolds were subjected to mineralization under optimal conditions. From the experimental results, we observed that the formation of bone-like apatite into collagen was relatively abundant and si

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